Individual results may vary

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See how GIVLAARI may help reduce AHP attacks

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Description
GIVLAARI® (givosiran) is a prescription medicine used to treat acute hepatic porphyria (AHP) in adults.

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Rediscover your everyday

Individual results may vary

Description
GIVLAARI® (givosiran) is a prescription medicine used to treat acute hepatic porphyria (AHP) in adults.
See how GIVLAARI may help reduce AHP attacks

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Reduces levels of neurotoxins

GIVLAARI reduces levels of aminolevulinic acid (ALA) and porphobilinogen (PBG), neurotoxins associated with attacks and other AHP symptoms.

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Fewer AHP attacks*

In a 6-month study, patients with AHP receiving GIVLAARI compared to those receiving placebo experienced fewer AHP attacks.*

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Fewer days of hemin use

In a 6-month study, patients with AHP receiving GIVLAARI compared to those receiving placebo had fewer days
of hemin use.

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Once-monthly dosing

GIVLAARI is given once a month as a subcutaneous injection (under the skin) by a healthcare professional.

*Attacks were defined as those that required hospitalization, urgent healthcare visit, or intravenous (IV) hemin at home.
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Do not use GIVLAARI if you have ever had a severe allergic reaction to GIVLAARI.

GIVLAARI can cause:

  • Severe allergic reaction

    Tell your doctor or nurse right away if you experience any of the following signs or symptoms of a severe allergic reaction during treatment:

    • Swelling – mainly of the lips, tongue or throat which makes it difficult to swallow or breathe
    • Breathing problems or wheezing
    • Feeling dizzy or fainting
    • Rash or hives
    • Itching

    If you have a severe allergic reaction, your doctor or nurse will stop GIVLAARI treatment right away and you may need to take other medicines to control the symptoms.

  • Liver problems

    Your doctor will check your liver function by doing blood tests:

    • Before you start using GIVLAARI
    • Once a month for the first 6 months of treatment
    • And when they think it is needed

    If these tests show abnormal results, your doctor or nurse will decide whether to temporarily interrupt or stop treatment with GIVLAARI.

  • Kidney problems

    Your doctor will check how your kidneys are working while you are using GIVLAARI.

  • Injection site reactions

    GIVLAARI is given as an injection under the skin (called a "subcutaneous injection"). Reactions to this injection may happen during treatment with GIVLAARI.

    Tell your doctor or nurse right away if you experience any of the following symptoms of an injection site reaction during treatment: redness, pain, itchiness, rash, discoloration, or swelling around the injection site.

What are the common side effects of GIVLAARI?

The most common side effects of GIVLAARI are nausea and injection site reactions. These are not all the possible side effects of GIVLAARI. Talk to your doctor about side effects that you experience. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit v2ray免费机场订阅地址, or call 1-8 00-FDA -1088.


What is GIVLAARI?

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For additional information about GIVLAARI, please see full Prescribing Information.